syntheiz and study some of 2-(1-adamantyl)benzimidazoles derivsive

Author: giorgi buzaladze
Co-authors: tinatin bukia
Keywords: adamantane, benzimidazole, sinthesis of adamantyl benzimidazole
Annotation:

The Annotation The growth of viral and infectious diseases is a significant problem in the medicine and pharmacology. For today one of actual problem is creation of low toxic and highly effective preparations. Research of adamantane fragment containing new derivatives and synthesis and studies of their pharmacological properties are actual . 2 - (1 - adamantyl) benzimidazole are characterized antiviral and antimicrobial activity, and in the living cell the concentration of 20 μM is no toxic. By the search of new preparationa which characterized a wide range of pharmacological properties and have a antiparasitic and anti infectious effects, is carried out the synthesis of new 2 - (1 - adamantan)benzimidazole and 5 (6)-nitro-(1-adamantyl)benzimidazole . By the reduction of nitro product in variety of conditions are obtained 5 (6)-amino-2-(1- adamantyl)benzimidazole. Studied the reactions of amine’s with aromatic aldehydes and carboxylic acides. Synthesized Schiff bases and amides. The structure of the obtained compounds are established by IR, UV, and NMR - Spectral data.

Lecture files:

2-(1-ადამანტილ)ბენზიმიდაზოლის ზოგიერთი წარმოებულის სინთეზი და შესწავლა [ka]